HOME학술지천식 및 알레르기

Title Clinical Relevance of Specific IgE Antibodies to Component Allergens in Adult Meat Allergy
Author Hyun Jung Jin1, Joo-Hee Kim2, Young-Hee Nam1, Eui-Kyung Hwang1, Yoo-Seob Shin1, Young-Min Ye1 and Hae-Sim Park1
Place of duty 1Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, 2Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Bovine serum albumin (BSA) and swine serum albumin (SSA) have been known as major allergens in beef and pork allergies. The aims of this study were to assess the diagnostic values of specific IgE antibodies to BSA and SSA and to evaluate predictive values for cross-reactivities in patients with adult meat allergy. Methods: Twenty-one adult patients with meat allergy and 15 healthy controls were enrolled for this study. Serum specific IgE to beef, pork, milk, BSA and SSA was measured by using immunoCAP (Phadia, Uppsala, Sweden). Patients were divided into 3 groups: those sensitive to beef (group I, n=4), those sensitive to pork (group II, n=10), and those sensitive to beef and pork (group III, n=7). Results: There were no significant differences in sex and manifestations to meat between the 3 groups, whereas age was significantly lower and the total IgE level was significantly higher in group III. The serum levels of specific IgE to BSA and SSA were significantly higher in the 3 groups than in the control group. The sensitivities of specific IgE levels to BSA and SSA, as assessed using receiver operating characteristic analysis, were 36.4% and 52.9%, with specificities being 100% for each. Conclusion: The results of this study suggest that the levels of specific IgE to BSA and SSA may have low sensitivities for the diagnosis of meat allergy and the evaluation of cross-reactivities between meat allergens. (Korean J Asthma Allergy Clin Immunol 2011;31: 0-287)
Key_word Serum albumin, bovine; Allergens; Food hypersensitivity
Publication info Korean J Asthma Allergy Clin Immunol 2011 Dec; 031(04): 281-287.
제 목 성인 육류알레르기 환자에서 성분항원 특이 IgE 항체의 진단적 의의
저 자 진현정1ㆍ김주희2ㆍ남영희1ㆍ황의경1ㆍ신유섭1ㆍ예영민1ㆍ박해심1
소 속 1아주대학교 의과대학 알레르기내과학교실, 2한림대학교 의과대학 성심병원 호흡기알레르기내과학교실
출판정보 대한천식알레르기학회지 2011 Dec; 031(04): 281-287.