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Title Clinical and Immunologic Evaluations of Immediate Hypersensitivity to Cefaclor
Author Young-Hee Nam1, Jeong Eun Kim2, Eui-Kyung Hwang1, Hyun Jung Jin1, Yoo Seob Shin1, Young-Min Ye1, Dong-Ho Nahm1 and Hae-Sim Park1
Place of duty 1Department of Allergy, Clinical Immunology, Ajou University School of Medicine, Suwon, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Cefaclor is commonly prescribed for various infectious diseases. It is known as a major causative antibiotic that induces drug hypersensitivity reactions. The aim of this study is to evaluate clinical and immunologic features of cefaclor immediate hypersensitivity. Methods: We conducted a retrospective study on the patients with histories of immediate hypersensitivity to cefaclor at Ajou University Hospital between January 2002 and February 2011. Serum specific IgE to cefaclor was measured using the ImmunoCAP system. Results: Fifty patients were enrolled in this study. The most common immediate hypersensitivity reaction was anaphylaxis (38/50, 76%), followed by urticaria/angioedema (12/50, 24%). High serum specific IgE to cefaclor was noted in 40 patients (80%). There were no significant differences in clinical parameters whether the patients had serum specific IgE or not, except that serum total IgE level was higher in patients with high serum specific IgE to cefaclor (P=0.042). Serum specific IgE to penicillin was detected in 26.1% of the patients with high serum specific IgE to cefaclor, while serum specific IgE to aminopenicillin was not found in any of the study subjects. Conclusion: Immediate hypersensitivity to cefaclor occurred mostly through the IgE-mediated mechanism, and anaphylaxis was the most common manifestation. Cross reactivity with penicillin was noted in 26% of the patients, but no cross reactivity with aminopenicillin was noted. (Korean J Asthma Allergy Clin Immunol 2011;31:192-198)
Key_word Cefaclor; Hypersensitivity, immediate; Immunoglobulin E; Cross-reactivity
Publication info Korean J Asthma Allergy Clin Immunol 2011 Sep; 031(03): 192-198.
Full-Text
제 목 Cefaclor 즉시형 과민반응을 나타낸 환자들의 임상적 및 면역학적 특징
저 자 남영희1ㆍ김정은2ㆍ황의경1ㆍ진현정1ㆍ신유섭1ㆍ예영민1ㆍ남동호1ㆍ박해심1
소 속 1아주대학교 의과대학 알레르기내과학교실, 2성균관대학교 의과대학 삼성창원병원 내과학교실 호흡기내과
출판정보 대한천식알레르기학회지 2011 Sep; 031(03): 192-198.